‘Did drug-affected Allison jump?’

A court has heard Allison Baden-Clay could have 'jumped to her death' while taking anti-depressant drugs.

IT is day 16 of the trial of former Brookfield real estate agent Gerard Baden-Clay, 43, who stands accused of murdering his wife Allison Baden-Clay, 43, on April 19, 2012.

Baden-Clay has pleaded not guilty in the Supreme Court in Brisbane.

Allison Baden-Clay put her husband's phone on charge at 1.48am and then went for a late night walk "to clear her head" on the day she disappeared, a Supreme Court jury was told yesterday.

Defence barrister Michael Byrne QC in his closing address to the Supreme Court in Brisbane put to the jury that the Brookfield mother-of-three first took a 100mg tablet of the antidepressant Zoloft before leaving the house in her walking clothes.

He said Ms Baden-Clay might have decided to walk out into the night, further than usual, against a background of mental turmoil over her husband's long-running affair, which they had discussed in detail the previous two nights; the possibility she would run into his mistress at a real estate conference the next day; and her failure to bear him a son.

Jurors in the Baden-Clay murder trial have been told they may find his morals despicable and his behaviour abhorrent, but the defence argued those actions don't make him a killer

Mr Byrne said the drugs in Ms Baden-Clay's system would peak in her blood stream and be absorbed by 4am. He said it was possible, with an increased dose that she experienced disorientation brought on by "serotonin syndrome" or perhaps just the greater than usual aberrant side-effects of Zoloft.

"And some time, for some reason, she ends up in the river," he said. "The autopsy report can't rule out drowning, it can't rule out a possible fall, a jump from the bridge which could have rendered her unconscious, and either drowning or dying in the river."

He told the jury it was a scenario they might reject, but it was one which they might think was open to them on the evidence.

Gerard Baden-Clay, 43, has pleaded not guilty before Justice John Byrne to murdering his wife and dumping her body 13.5km away at the Kholo Creek Bridge at Anstead on April 19, 2012.

The defence and prosecution in the trial of Gerard Baden-Clay will today begin summing up their cases.

Mr Byrne gave a forensic and methodical closing address to the jury at the opening of the trial's fifth week.

He asked they reject that Baden-Clay killed his wife during a violent confrontation, motivated by the financial gains of her life insurance policy or the promise of leaving to start a new life with mistress Toni McHugh.

He then drew the jury's attention to Baden-Clay's infidelity.

Follow the trial of the year day-by-day here:

DAY 15: 'She can't sleep, she's up alone, what if...'

DAY 14: 'You killed your wife.' 'No, I did not.'

DAY 13: Allison's journal 'untrue', says Baden-Clay

DAY 12: Baden-Clay's love triangle email trail

DAY 11: Baden-Clay's tears as he takes the stand

DAY 10: How it unfolded as the Crown rests

DAY 9: Plants on Allison found at her home

DAY 8: Jurors inspect site where body found

DAY 7: Neighbour's explanation for scream

DAY 6: Scratches not typical of razor

DAY 5: Listen to triple-0 call to police

DAY 4: Accused told lover to lie low

DAY 3: Neighbours heard screams

DAY 2: Daughter's tape brings tears

DAY 1: Photo shock in murder trial

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